We generated a cerebellum specific knockout mouse for Srd5a3, a gene involved in the initiation of N-glycosylation. However, little is known about the molecular mechanisms underlying these defects. Impairing the N-glycosylation pathway at early steps produces broad neurological symptoms identified in congenital disorders of glycosylation. Neuromics' Cortical Neurons & Kinetic NeuroTrack A.Proper brain development relies highly on protein N-glycosylation to sustain neuronal migration, axon guidance and synaptic physiology.Neuron-specific class III beta-tubulin (TuJ1) Stai.Alzheimer's Disease (8) Amyotrophic Lateral Sclerosis (9) Antibodies (7) Apoptosis Detection (9) axonal regeneration (3) Cancer Research (8) Cerebral Ischemia (4) diabetes (7) e-18 Primary Rat Neurons (12) embryonic stem cells (19) enteric nervous system (5) FLICA (5) FLIVO (2) Glia Markers (8) Glial Markers (15) Hippocampal Neurons (6) human embryonic stem cells (3) Human Neural Progenitors (11) Human Neurons (9) Hypothalamic Neurons (2) Immunocytochemistry (5) Immunofluorescence (16) Immunohistochemistry (24) inflammatory response (13) MitoPT (2) Multiple Sclerosis (11) Neural Crest (2) Neural Progenitor Cells (7) Neural Stem Cell Markers (8) Neurofilament Markers (14) Neurogenesis (6) Neuronal Markers (17) Neuropathic Pain (19) Neuropeptides (8) Neuroprotection (4) neuroscience (4) Neurotoxicity (9) Neurotransmission (10) Nociceptive Pain (18) Obesity Research (7) Oligodendrocytes (9) Otx2 Antibody (2) Pain Research (27) Parkinson's Disease (11) placental mesenchymal stem cells (1) Polcaspase Kits (2) Primary Neurons (2) Purinergic Receptors Antibodies (3) Rett Syndrome (1) RNAi (4) S100A13 (1) Schwann Cells (10) siRNA delivery in-vivo (12) Spermatogenesis (2) Spinal cord injury repair (6) spinal cord regeneration (4) Stem Cell Differentiation (8) Stem Cell Differentiation Protocol (4) Stem Cells (13) STEMEZ hN2 Neurons (5) STEMEZ hNP1 Neural Progenitors (7) Straital Neuron Cultures (2) Thermal Hyperalgesia (1) Transfection (5) Western Blot (7) Western Blotting (9)
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